Plague, Inc. can be a very challenging game, especially if you play it in Black Plague mode. Your toughest enemy is the Cure so you spend most of the game fighting that enemy while developing diseases. To learn how to complete this challenging game mode, see Step 1 below.
Step
Step 1. Choose the right genetic modification
Before playing the game, you will gain the ability to apply modifications to the initial disease. This modification will help the disease survive and allow you to fight the Cure more easily. Once you've done that, you should be able to access almost all of the available options so you can choose the one that's best for you to complete Brutal Black Plague mode.
- DNA Gene – Catalytic Switch. This gene provides a DNA bonus by popping the blue Cure bubble which is needed later to fight the Cure.
- Travel Gene – Aquacyte or Suprression. Aquacyte is highly recommended because this option makes it easier for you to infect archipelagic countries like Greenland and Madagascar (Madagascar). Suppression is useful for spreading disease to areas whose land borders are closed.
- Evolution Gene – Ionised Helix (optional). This gene will give you DNA when devolving, but you should not devolve in this mode. Do not take genes that facilitate disease cure.
- Mutation Gene – Genetic Mimic. This gene makes the disease difficult to cure so it is very important to complete this mode.
- Environment Gene – Extremophila. This gene gives disease additional strength in all types of environments.
Step 2. Choose India as the first place to infect the disease
There is a lot of debate about which country should be used to spread disease, but India seems to be one of the starting locations that has the greatest chance of completing the game, as India has a large population, warm weather, and close proximity to China.
Other good locations that can be used as first places to spread disease are Egypt (Egypt), Saudi Arabia (Saudi Arabia), China (''China''), and Central Africa (Central Africa)
Step 3. Develop (evolve) Transmission mode before developing Symptom
You certainly want the virus to spread quickly and non-fatally before making it even more virulent and deadly. To do this step, start to collect DNA. When you have enough DNA to start modifying the disease, focus the modification on the upgrades listed below in the following order:
- Rodent 1
- Livestock 1
- Bird 1
- Rodent 2
- Livestock 2
- Birds 2
- Extreme Zoonoses – This option is only available if you develop each Transmission type to 2. This gene allows disease to spread between species quickly.
Step 4. Create a defense
After obtaining the required Transmission, it was time to increase the disease resistance. Focus on modifications to develop the defenses listed below in the following order:
- Cold 1
- Drug Resistance 1
- Cold 2
- Drug Resistance 2
Step 5. Develop some Symptom
When the disease has spread and can defend itself, it is time for you to make its presence known to people. Symptoms help spread disease, and with their help the spread of infection will increase very sharply. Once Symptom starts appearing, Cure creation will increase, so now you're in a race against time. Focus modification on the following Symptom:
- Pneumonic Plague
- Coughing
- Skin Lesions – There is a high chance that this symptom will mutate by itself.
- Sneezing
- Pulmonary Edema
- Pneumonia
Step 6. Wait until the Cure progress reaches 25%
Once you develop symptoms and the disease has spread, there's nothing you can do but wait for the Cure to develop. Be sure to keep popping the DNA bubble so you're ready to modify the disease as needed.
When the Cure progress reaches 25%, develop Genetic Reshuffle 1 and Drug Resistance 3
Step 7. Wait until the Cure progress reaches 75%
When you've reached this stage, you just need to focus on fighting the Cure. Every time you use Genetic Reshuffle, the Cure's progress will be hampered. When Cure progresses to 75% for the first time, evolve Hardened Reshuffle 1.
- When Cure progress reaches 75% again, evolve Hardened Reshuffle 2.
- When Cure progresses back to 75%, evolve Genetic Reshuffle 2.
- When the Cure progress reaches 75% again, develop Genetic Reshuffle 3.
- Make sure you keep popping the DNA and Cure bubbles.
Step 8. Develop a lethal Symptom
At this stage the disease should have infected almost everyone on Earth, so you can start killing them. Spend the DNA on the remaining Symptoms in the desired order. At this stage the Cure should have failed, because everyone is dying, so you don't have to fight it anymore.
Step 9. Keep trying
Playing Plague Inc. requires a lot of luck that appears randomly, and the whole strategy doesn't always work every time you play the game. However, this strategy managed to help many players to finish the game successively on the first try until the next few tries. Keep trying to complete the game and in the end you too can rule the world with Black Plague.
